16 pages, Producing sufficient food to satisfy nutritional needs is imperative for building a prosperous society. This study examined trends in agricultural yields, water and sanitation services, and nutrition indices in Nigeria. Secondary data from the FAO-FAOSTAT (2000โ2020) were utilized and analyzed using descriptive statistics, the respective coefficients of variation and determination, the Mann-Kendall trend test, the Pearson correlation and multivariate regression for statistical inferences. The results show trends for data on several variables. GDP per capita and population numbers were positively correlated with the number of children under five years of age who were stunted, and the proportion of population and number of people using safely managed and at least basic drinking water and sanitation services. A major result was the significant positive relationship between cassava yield and number of children under five who were stunted. Also, there was the negative influence of population numbers on cassava and maize yields. If not attended to, the outcomes of these relationships are expected to exacerbate nutrition insecurity and stunting in children under five. An improvement in the national indices on agricultural yields and nutrition security is imperative for the accelerated attainment by 2030 of the national nutrition security targets and the SDGs.