9 pages, Humans have improved plants for their utility through selective self-pollination, crossing, and progeny selection for >10,000 years, largely based on physical characteristics. Less than 200 years ago, the genetic basis of heritability in selection was revealed, enabling breeders to accelerate genetic gain. Breakthroughs in genomics and molecular markers for the past century have enabled breeders to locate and select genomic regions affecting desirable traits, improving breeding precision. Transgenesis has enabled crop insertion of desirable exogenous genes, enabling de novo functionality. These technologies, along with agronomic practices, have generated more than sixfold yield improvements in crops such as corn in the past century. Gene editing, with its unique ability to precisely edit, change expression, and move genes within a crop's genome, has the potential to be the next breakthrough technology. For this to come to fruition, it is critical to take a holistic view considering perspectives of scientists, farmers, regulators, and consumers.
